Would you avoid risankizumab in a patient with stricturing Crohn’s complicated by granulomatous bronchiolitis with stenosis who had to stop ustekinumab due to hemoptysis?

Unless there had been a rapid and dramatic beneficial response of the Crohn’s disease to ustekinumab, I would have little appetite for trying another IL-blocker. A different mechanism, like JAK, might be worth trying, but the serious pulmonary complication probably warrants steroid therapy. One coul...

Thanks for your question. I need some clarification on the scenario. Does the patient have an underlying diagnosis of bronchiolitis and had hemoptysis after starting ustekinumab, or did they develop the granulomatous bronchiolitis secondary to the ustekinumab (not as likely a scenario)? If the hemop...