Dermatology
Clinical insights on skin conditions, dermatologic procedures, and treatment approaches from practicing dermatologists.
Recent Discussions
Do all patients initiating omalizumab need to have it administered in a healthcare setting?
In the trials, all cases of anaphylaxis were on first administration--suggesting it is not intrinsic to drug and is more likely because you are giving it to a group of people who may be more susceptible to anaphylaxis in general. FDA has cleared at home use, so my general approach in a patient witho...
What is your advice to patients with IBD who are on biologic therapies and planning for pregnancy?
Biologics are effective therapies for many autoimmune conditions, including IBD. The best outcome of a pregnancy is if a patient is in remission at the time of conception, which means she does not stop her therapy to get pregnant. Indeed, there are studies on women with nonspecific infertility who w...
Would you consider anti-IL-5 therapy (mepolizumab or benralizumab) to either prevent or treat the more severe manifestations of eosinophilic granulomatosis with polyangiitis, such as "infiltrative" (e.g., cardiomyopathy, pulmonary infiltrates, or gastroenteritis) or "vasculitic" (e.g., neuropathy, palpable purpura, or glomerulonephritis)?
Yes, I would consider early starting biologics for infiltrative EGPA.
What treatment modalities have you had success with for treating extensive molluscum in the pediatric population?
I've had very good success with the use of oral cimetidine, 400 mg PO tid in children. Usually, they remain on this tx for 4-6 weeks with sig clearing beginning by the 1st 2-3 weeks. I also use tretinoin gel 0.1% qd-bid to the more stubborn lesions if necessary.
What is your diagnostic and treatment approach for patients hospitalized with erythroderma?
I would like to know details regarding the patient's medical and family history since underlying primary dermatologic disorders, onclogic disorders, genetic disorders, medications, and infections can trigger erythroderma with medical complications.
Do you change your approach to prednisone taper based on rituximab dosing regimen when treating patients with pemphigus?
My approach to prednisone course/tapering at treatment outset or subsequent rituximab is typically dictated by clinical parameters, specifically PDAI/severity and potential comorbidities, rather than rituximab dosing regimen. This paper supports the notion that similar cumulative steroid exposure an...
Are there patients with pemphigus whom you plan to give additional doses of rituximab even if they are in complete remission at six months from their initial dose?
It depends on what you consider "complete remission". Antibody levels and types, both before and after treatment, probably help predict relapse. Generally, we plan to give another rituximab dose at 6 months and reassess a few months ahead to see if any predictors of relapse are present, with a fairl...
What topicals have you had success with treating body acne?
Agree with Jim Leyden that systemic therapy, especially isotretinoin, is far superior to topical therapy in treating truncal acne. However, in patients who refuse systemics, some of the newer topicals may be helpful. The newer retinoid formulations, trifarotene cream and tazarotene lotion, both have...
What treatment modalities have you had success with for treating sebaceous hyperplasia?
I have used light electrodesication with a blunt tip needle with good effective results without visible scarring for the vast majority of patients. I find that it is efficient and less expensive than laser modalities. The procedure is uncomfortable for my patients and typically I need to use topical...
Is it safe to use one TNF inhibitor (e.g., infliximab) in a patient who has had a severe allergic reaction to a different TNF inhibitor (e.g., adalimumab)?
The short answer is yes - it is ok to proceed with a different TNFi. First, it is important to determine whether the reaction was truly allergic or a nonspecific infusion reaction instead. If possible, obtaining a serum tryptase level at the time of the reaction can help clarify. Realistically, this...