Neurology
Expert perspectives on neurological conditions, stroke management, movement disorders, and neuromuscular disease.
Recent Discussions
When do you switch to a different DMT in multiple sclerosis patients planning for pregnancy?
There are several key differences between the reported French study and the often-used practice in the US. In the French registry, nearly 50% of patients with the diagnosis of relapsing MS (diagnosed by either Poser or early McDonald criteria) were not on DMT. While it was common in the early 1990s ...
How do you manage daytime somnolence without a clear cause?
Throw a broad net out for the evaluation because we don't know how much has a physiological component and how much is mental/emotional. At intake, I get a moderately comprehensive set of labs. Rating Scales like HAMA, HAM-D, PHQ-9, Epworth Sleepiness Scale, and a ROS (Review of Systems) are done. I...
What factors would prompt you to refer a patient for a surgical epilepsy evaluation who has not yet failed two anti-seizure medications?
This is a good question, and of course, the discussion with the patient regarding their diagnosis and treatment plan is important. There are also expert consensus guidelines that help to clarify this (Jehi et al., PMID 35842919) and that most of us would ascribe to in these cases. Specifically, when...
How do you approach the use of newer anti-seizure medications for epilepsy patients on DOACs?
Levetiracetam and valproic acid: A nested case-control study published in 2021 (Gronich et al., PMID 34287842) in patients with afib identified an increased risk of stroke/systemic embolism with levetiracetam and valproic acid. This was followed by a few retrospective studies published in 2022 and ...
What lifestyle choices are helpful in reducing the risk of or slowing cognitive decline?
Regular daily physical exercise. A healthy diet: for example, the MIND diet: low in fat and sugar, high in vegetables and fruits, and regular hydration. Be mentally active. Participate in social activities. Get adequate sleep (7-8 hours nightly). Manage stress. Limit alcohol and avoid smoking Perio...
When do you use rozanolixizumab for Musk MG?
Rozanolixizumab is unique in that it is the only FDA approved treatment for both AchR and MuSK autoantibody (+) MG and works by reducing total IgG levels, including IgG4. MuSK (+) MG is mostly a pathogenic IgG4-mediated disorder with direct inhibition of protein interactions and damage of the post-s...
When do you consider tapering tocilizumab in patients with GCA in remission?
This is a timely question and recent data sheds some light on this important topic. The risk of GCA relapse is approximately 50% (Mainbourg et al., PMID 30951256) in all comers. The GIACTA trial (Stone et al., PMID 28745999) utilized a one-year course of TCZ. A recent publication of the extension ph...
How do you counsel patients with Parkinson's disease who are interested in starting GLP-1 agonists for neuroprotective benefits?
This is an important question, thank you. The Parkinson's disease community has been desperate to find an intervention other than exercise that can slow the progression of the disease and provide neuroprotective benefits. We might be heading in the right direction with glucagon-like peptide-1 (GLP-1...
Have you seen improvement in non-migraine-type headaches with the usage of drugs targeting CGRP?
For prevention, I have only used the 4 monoclonal antibodies or the 2 preventive gepants for documented migraine with and without aura, and also for cluster headache. I tend to use the one that is approved for cluster headache, eptinezumab, at the higher dose of 300 mg via IV infusion. For acute car...
How long would you stop standard GBM radiotherapy if the patient had a fall with minor head trauma?
I would do everything possible to minimize or ideally avoid treatment breaks, given no intracranial bleed. I would evaluate skin dose over the area of laceration and consider adapting the plan to meet skin constraints or lower dose to the suture if possible and not already low. If significant swelli...