Neurology
Expert perspectives on neurological conditions, stroke management, movement disorders, and neuromuscular disease.
Recent Discussions
How do you discontinue ketogenic diets previously used as a treatment for epilepsy?
The caveat in my answer is that I use ketogenic diets (mostly MAD) in adults with medically refractory epilepsy. We typically advise patients to discontinue gradually by adding back ~5 gm carbs/week until they are eating more "normally." Sometimes these patients never go back to their previous Stand...
What criteria are used to choose a specific dose of aspirin in ischemic stroke?
In my training and current practice, most stroke specialists have adjusted from the standard 81 mg aspirin dose (one-size-fits-all) to weight-based dosing. A meta-analysis of RCTs (Rothwell et al., PMID 30017552) suggests that low-dose aspirin may not suffice for stroke prophylaxis for patients who ...
When starting a patient with MS on a DMT, how frequently should MRIs be ordered to assess whether the treatment is effective?
I typically obtain an MRI brain around 6 months after initiation of a new DMT and then monitor MRIs yearly thereafter, unless new clinical symptoms develop.
Does IVIG or subcutaneous Ig interfere with monoclonal antibody therapy (i.e. dupilumab, infliximab, rituximab, etc)?
I definitely agree with Dr. @Dr. First Last concerns. For what it’s worth, I use a lot of IVIG in combination with monoclonal medications in my myositis clinic, and have anecdotally noted multiple instances in which I feel that the efficacy of one of those monoclonals seems to have been worse when t...
What workup do you consider for a developmentally typical child with multiple large café au lait macules but no other signs of neurofibromatosis?
The likelihood that this is NF1 depends somewhat in part on the age of the child in question. In infants and toddlers, cafe-au-lait macules are usually the first and only clinical sign of NF1. Most children with NF1 will develop skin fold freckling in early childhood, and the majority (probably 60-7...
Would you consider using DOACs as a bridge to warfarin instead of heparin or LMWH?
I would feel very comfortable bridging with apixaban, given its relatively short half-life and fairly quick absorption. I think it is very similar to bridging with Lovenox. More importantly, it usually takes at least 24 hours until heparin IV gets to therapeutic levels - it is often too high or too ...
What holistic treatments do you recommend for patients with migraine without aura?
Before considering alternative or holistic treatments, first, assess whether both preventive and abortive treatments have been taken correctly and if there is no evidence of medication overuse. Cost and side effects often limit compliance. Lifestyle modification (which could be broadly considered as...
How do you counsel patients with mild congenital myopathy about exercise limitations?
There are many reasons why all patients with muscle disorders should exercise. Many studies have shown improvements in aerobic capacity and some have shown improvements in functional capacity (i.e., 6MWT). Furthermore, many patients with neuromuscular disorders tend to avoid exercise and this is a c...
Would you consider using IVIG for POTS in the absence of any clear autoimmune condition or abnormal antibodies?
I completely agree with the answer above. It would be a pretty rare consideration, overall. Recent placebo-controlled and blinded studies examining the efficacy of IVIG for idiopathic or antibody-associated (FGFR, TSHDS) small fiber neuropathy found no benefit of the treatment in terms of small fibe...
What type of visual disturbance qualifies as a visual aura?
Visual aura should be a time-limited neurologic event (5 minutes to 60 minutes) with or without migraine headache. It can contain positive (e.g., flashes of light) and/or negative (e.g., scotoma) visual phenomena. It is often toward one side of the visual field but is binocular (comes from both eyes...