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How do you counsel and manage joint pain after isotretinoin treatment?

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Dermatology · University of Pennsylvania

Firstly, if one starts with 0.5mg/kg joint symptoms rarely happen. My approach is to temporarily stop isotretinoin until symptoms pass and then start at half the previous dose and treat until clear. The ineffective dose was never found. We know now the critical factor in relapse is age-no matter wha...

Would you switch azathioprine to a different immunosuppressant if a controlled patient with SLE develops melanoma and/or non-melanoma skin cancer?

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Rheumatology · MUSC Health

This is a difficult question with no definitive research-proven answer. Clearly, most of our drugs do enhance the chance of melanoma and nonmelanoma skin cancer. If one does a literature search the only one of our drugs that has not been reported to increase the chance for relapse of melanoma is Tac...

How do you counsel patients interested in estrogen containing oral contraceptives who have migraine with aura?

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Neurology · Atrius Health

Outside of patients whose attacks are suggestive of hemiplegic migraine, I do not typically avoid the use of estrogen-containing OCPs. While it is my understanding that a number of international organizations and many neurologists (as well as Ob/Gyn) recommend their avoidance, there are several revi...

What approach to antipsychotics do you take with patients with primary thought disorder who are now geriatric?

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Psychiatry · McLean Hospital/Harvard Medical School

The primary goal is to manage psychotic symptoms effectively while minimizing adverse effects, particularly those that may exacerbate cognitive impairment. Older adults may experience altered pharmacokinetics and pharmacodynamics, which can affect the efficacy and safety of antipsychotic medication...

Do you use any alternative or non-FDA-approved treatments for smoking cessation?

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Psychiatry · Morris Abby H Office

For a non-medication, non-nicotine option, NADA auricular acupuncture has had some evidence-based success in tobacco cessation. It can also be somewhat helpful for anxiety and insomnia. The results are not always mind-blowing, but the risks are also not high so, in general, the outcome tends to be w...

What are the current clinical practices for TEE to guide cardioversion and anticoagulation duration post-cardioversion for Afib/flutter in patients following left atrial appendage closure?

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Cardiology · Uva Health Heart And Vascular Center Fontaine

Right now, there is not a great deal of data to guide us to answer this question. In general, the safest thing from a stroke prevention standpoint would be to adhere to the same guidelines that we would for patients without left atrial appendage occlusion devices. However, of course, most of these p...

How do you manage calcium and vitamin D supplementation in patients with sarcoidosis on chronic steroids?

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Rheumatology · Virginia Commonwealth University Health System

This is a great question with very limited data to help answer it well. The first-line therapy for sarcoidosis is corticosteroids, and chronic use can lead to decreased bone mass. Of course, Vitamin D supplementation is a very important factor in rebuilding bone mass. In sarcoid patients, this issue...

How do you manage and adjust Parkinson’s medication if a patient has worsening orthostatic hypotension while being treated with carbidopa/levodopa?

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Neurology · New York Medical College

Levodopa is such an important pillar of Parkinson's therapy that it is often necessary to continue this drug despite the worsening of orthostatic intolerance.This is a step-wise approach (i.e., don't go to step 4 if you haven't addressed step 2): Ensure that the patient is getting symptomatic benefi...

What work up do you pursue for a thorough evaluation in patients that present with a potential diagnosis of dermatitis artefacta?

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Psychiatry · Oklahoma State University

I have found dermatologic complaints some of the most challenging in my psychiatric practice. Dermatitis artefacta (DA) occurs when an individual produces self-inflicted skin lesions in order to assume the sick role, making it a type of factious disorder. When evaluating a patient with suspected DA,...

What factors should guide the choice between fosfomycin and nitrofurantoin for uncomplicated cystitis, given the reduced efficacy of fosfomycin?

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Infectious Disease · Massachusetts General Hospital

I agree with the authors you reference that, though fosfomycin is listed as a first-line option in the 2011 IDSA UTI guidelines for uncomplicated cystitis, our assessment of its efficacy has changed somewhat since then.We now have two larger randomized controlled trials that demonstrate that women r...