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How will you adjust your approach to steroid taper in patients with PMR also on sarilumab?

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Rheumatology · Harvard Medical School- MGH

I would try to replicate the prednisone taper followed in the SAPHYR study that weaned patients off over 14 weeks, understanding that there may be patients that won’t be able to taper the prednisone so aggressively or may benefit, in the opinion of the treating physician, from longer tapers (e.g., 4...

What is your preferred management for eruptive vellus hair cysts?

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Dermatology · Northwestern University

I have not found any topical medication that helps to clear these and often end up doing quick electrodessication one by one for these small cysts.

Do you routinely prescribe PPI prophylaxis for myeloma patients who will be on low-dose aspirin and weekly dexamethasone?

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Hematology · UMass Chan Medical School

Depends on the dose of weekly dexamethasone. If 40 mg weekly, would use PPI. If given along with cyclophosphamide as CyBorD, would use PPI regardless of dose of dex; if symptomatic gastritis on aspirin or dex, will use PPI even with lower doses of dex.

In a young female with severe osteoporosis due to congenital estrogen deficiency, can estrogen be prescribed if genetic testing for congenital disorders reveals a heterozygous Factor V Leiden mutation?

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Hematology · University of Wisconsin

First of all, I don't think testing for inherited thrombophilia is warranted in a patient with no personal or family history of thrombosis. Given the multigenic nature of thrombophilia and our limited ability to test for it, it's difficult if not impossible to determine an individual's risk of throm...

What is the risk of serious bacterial infection in a febrile solid tumor patient who has not yet started cancer-directed therapy and has normal cell counts with no central line?

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Pediatric Hematology/Oncology · Kidz Medical Services, Inc

This depends on the type of the tumor, the location, and the individual circumstances. It may not be wrong in this scenario to draw blood cultures and give a dose of ceftriaxone pending 24-hour results, but this practice may also vary based on these different variables e.g. RMS of paranasal-ear area...

In patients taking biologics who are planning joint replacement and are known MRSA carriers do you perform decolonization prior to surgery?

Is there a role for phlebotomy in secondary polycythemia?

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Hematology · Johns Hopkins University

Prefatory to answering the question, I think it's important to specify the full nature of the problem because there is confusion in the hematology literature about the criterion used to define erythrocytosis as well as the phlebotomy target in secondary erythrocytosis. Currently, hematologists use t...

Do you offer iron supplementation to a patient with iron studies that are normal (including normal ferritin) except for low iron saturation?

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Hematology · Georgetown University School of Medicine

The answer is absolutely and positively yes. A low percent saturation of transferrin has an extremely high concordance with absent marrow hemosiderin and frankly, in today’s parlance is the best indicator of “iron need”. While the ferritin is marvelous at confirming iron deficiency if low (with or w...

How do you approach treating acute and chronic Demodex folliculitis?

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Dermatology · Thomas Jefferson University Hospital

Demodex folliculitis is often a diagnosis of exclusion and is considered when treating refractory rosacea, bacterial or fungal folliculitis. The organism can be found on normal skin and is seen on KOH prep of a skin scraping. Combination treatments with oral and topical medications have been found t...

Do you routinely perform mammograms for women that underwent nipple-sparing mastectomy with reconstruction after a breast cancer diagnosis?

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Radiation Oncology · Varian Medical Systems/Allegheny health network

We don’t perform mammograms routinely for this subset unless clinically indicated.