Pulmonology
Physician discussions on respiratory conditions, critical care, interstitial lung disease, and pulmonary procedures.
Recent Discussions
Is there a role for biologics to help patients with ABPA who are steroid responsive and have removed their allergen insult, but continue to have an elevated serum IgE and incomplete resolution of symptoms return to their baseline functional status?
We have a fairly large number of ABPA patients on Omalizumab. It works great. One of the issues we frequently encounter is that ABPA patients sometimes have too high of IGE counts for the approved highest Omalizumab dosage. In these patients, we initially treat them with standard prednisone therap...
Is positive pleural fluid cytology from pleural mesothelioma considered M+?
No, positive pleural fluid cytology is not considered M1 disease based on AJCC 8th edition staging. Pleural effusion with positive cytology is often present even in early stage disease.Initially, MPM forms small, discrete nodules on the parietal pleura surfaces, convalescing into confluent sheets of...
Do you favor timely bronchoscopy for diagnostics over close surveillance in mildly symptomatic patients with CT findings suspicious for NTM infection who are not able to expectorate?
Yes, I do favor FOB to obtain BAL in symptomatic patients with suspected NTM.
Do you use steroids in the management of PJP pneumonia with severe hypoxia in HIV negative patients?
I only saw about 4 (non-HIV) patients with PJP before AIDS hit the US in 1981. Like others caring for AIDS patients in the 1980s, PJP was incredibly common I saw at least 200 cases over the years. Until AIDS, there were never enough non-HIV patients to do a RCT to look at steroids. Thanks to the wel...
Do you favor the use of maximal inspiratory/expiratory pressure measurement or supine spirometry in the evaluation of a patient with suspected respiratory muscle weakness?
In practice, we often perform both in the same session. Supine spirometry has the advantage of assessing the orthopnea that is a common complaint among my patients with neuromuscular disease. Also, many of our patients report that the MIP/MEP maneuver is difficult to perform and they feel it underes...
Do you use or recommend clinical severity scores or other parameters in helping prognostication in patients with refractory status epilepticus?
I do not find prognostication scores in status epilepticus to be particularly helpful in driving care and discussing prognosis with families. We track the "Status Epilepticus Severity Score” (STESS) for quality improvement only to determine presentation severity. For prognosis, the refractoriness of...
Do you utilize phrenic nerve EMG in patients with diaphragmatic issues?
Diaphragm muscle needle EMG is definitely a useful tool to assess patients with suspected respiratory muscle weakness/paralysis. It can differentiate neurogenic from myopathic disorders and it can help with prognostication. However, many providers, including myself, are not very comfortable with "bl...
What are some important considerations for use of ACE inhibition in scleroderma renal crisis patients who require dialysis?
Yes, captopril is dialyzable with about ~35% of the drug being removed during intermittent hemodialysis. It is not recommended to be used if an AN69 hemofilter is used for iHD, as it is associated with anaphylaxis with that particular filter. There does not appear to be any contraindications to usi...
Should checking a urinalysis with reflex to culture be part of the standard work up for fever in an ICU patient with a urinary catheter?
Yes, as part of a broad workup for infectious and non-infectious causes of fever, and with many caveats. Patients in the ICU are at high risk for diagnosis with CAUTI, yet as I think you are applying, this is a difficult diagnosis to make given the inability of many patients to give a history (or fo...
How would you manage subclinical ILD associated with MDA-5 Dermatomyositis?
Subclinical ILD in anti-MDA5 is like a time bomb waiting to explode. Would do aggressive monitoring for ILD symptoms/tests and give at least 1st line immunosuppression with CellCept or tacrolimus.