Radiation Oncology
Expert insights on radiation treatment planning, techniques, toxicity management, and multimodal cancer care.
Recent Discussions
What is your experience with Gelclair for oral mucositis during head & neck radiotherapy?
I used Gelclair for my patients regularly till a few years ago. However, I did not find a significant difference in the rates of mucositis among those who did and did not use this product. That is my anecdotal experience and I would be curious to hear other thoughts from those who are routinely reco...
How would you treat a patient with a granular cell tumor of the breast with positive margins following excision?
This is a rare diagnosis, and recurrence has rarely been reported with incomplete excision. However, positive margins alone may not be an indication to re-resect benign granular cell tumor. MDTB discussion is key here. Reports suggest that the long-term prognosis is excellent even with positive marg...
How do you treat SNUC?
There’s no standard treatment. Suitable for gross total resection: surgery and postop RT and concomitant chemo.Not suitable for GTR: chemo RT or induction chemo and reevaluate for surgery and postop RT chemo.
Is FAST-Forward/ultra-hypofractionation suitable for an early-stage breast patient after a lumpectomy with oncoplastic reduction?
Yes, FAST-Forward is fine after oncoplastic reduction as long as dose homogeneity criteria can be met (V105 < 5%).
What dose and OAR constraints do you use for boost with IMRT or SBRT when a patient with cancer of the cervix is not a candidate for brachytherapy?
Concurrent chemoradiotherapy plus brachytherapy boost (intracavitary or interstitial) is the standard of care in patients with locally advanced cervical cancer. In light of published data suggesting inferior survival if brachytherapy is omitted from definitive treatment, we do not recommend utilizin...
For locally advanced adenocarcinoma of the maxillary sinus, how should the neck be managed?
ENI if high grade
Would you add a brachytheray boost to a locally advanced cervical cancer after surgical resection and pelvic RT?
In general, a brachytherapy boost following external radiation is not standard when treating women for locally advanced cervical cancer post hysterectomy. Neither of the 2 major adjuvant GOG trials (92 and 109) allowed a brachytherapy boost, and even the currently open GOG trial, GOG 263, does not i...
Which normal brain dosimetric constraints are most important when treating brain mets with SRS?
Great point, esp. about the PTV margin issue. Some people argue you don't really need to add a mm or two of margin; "We have sub-mm localization error." A 0.7 mm error in three single dimensions equals a 1.2 mm error for the scalar in 3D (as 1.2 = ((0.7^2)+(0.7^2)+(0.7^2))^0.5), so I think it's a si...
What approach do you take to determine dose constraints for conventionally fractionated reirradiation of the head and neck?
Great question, very challenging scenario.In general, try to minimize the margins for re-RT, and use IGRT, especially if you are close to the neurologic critical structures. (Optics, brainstem, spinal cord, plexus, temporal lobe.)Specific doses and whether you exceed limits: that really depends on w...
Would you consider starting immunotherapy concurrently with whole brain radiation for newly diagnosed metastatic (BRAF negative) melanoma with multifocal symptomatic brain metastases?
This is a challenging clinical situation. In part, the approach depends on the number and size of the CNS lesions. However, I do not recommend the use of WBRT for my patients, as it has not demonstrated a survival benefit. In addition, in the adjuvant trial comparing WBRT to observation, it did not ...