Radiation Oncology
Expert insights on radiation treatment planning, techniques, toxicity management, and multimodal cancer care.
Recent Discussions
How do you manage the timing of adjuvant therapy in a patient with a glioblastoma and a post-operative surgical site infection?
There have been several studies on the timing of adjuvant therapy for glioblastoma including our institution https://www.ncbi.nlm.nih.gov/pubmed/26440447. In general, our practice has been to start adjuvant radiotherapy as soon as reasonably possible. If a glioblastoma patient has postoperative surg...
Do you routinely hold immunotherapy during whole brain radiation?
I don't routinely withhold immunotherapy during whole brain radiotherapy but would look at all aspects of the case including performance status, labs, goals of care, etc.. Alternatively with SRS I don't routinely withhold immunotherapy as well.
How do you manage SCC metastasis to the parotid with unknown primary?
Guidelines for this situation have been published:https://www.ncbi.nlm.nih.gov/pubmed/22076982After ruling out the possibility of a mucosal primary, in the setting of a presumed occult cutaneous squamous cell carcinoma, I would typically suggest parotidectomy, with regional lymphadenectomy (for pati...
Can short course radiation therapy (5 Gy x 5 fractions) be given for low lying rectal tumors, near the sphincter but not involving it?
The anal sphincter toxicity of short-course radiation therapy versus long-course chemoradiation therapy is an interesting question. We know from a robust experience in anal squamous cell carcinoma that long course radiation does carry a significant risk of sphincter tone issues in the long-term, eve...
In what situations do you obtain both a pelvic MRI and EUS for rectal cancer staging and treatment planning?
I'm not sure that T2N1 is boderline - preop CRT is still a standard of care for node positive disease. Generally, thin slice (3mm or less) MRI with external (if available) or internal coil is the preferred staging modality for patients with newly diagnosed rectal cancer. Utilize the T2 images and c...
How would you counsel a patient who will undergo breast irradiation in which a large port wine stain is overlying the breast?
Port-wine stain (PWS) is the second most common congenital vascular malformation characterized as ectatic capillaries and venules in the dermis that clinically appears as a deep red to purple patch on the skin. Like other benign vascular abnormalities (symptomatic hemangiomas of spine, etc) and prio...
Would you recommend concurrent chemotherapy for a T1N1 oropharynx cancer if the patient underwent excisional biopsy of the node and was found to have ECE?
Let's look at it this way. If he had surgery with neck dissection and had pT1,N1 with ECE, one would recommend concurrent chemoRT post-op. Both the EORTC and RTOG trials included this subgroup of patients. The subset analysis of the long term follow up of RTOG 9501 showed increased local control and...
When do you offer salvage prostate bed RT to patients who have a biochemical recurrence >5 years after RP?
While retrospective data consistently suggest that biochemical outcomes (and possibly also distant metastases and prostate cancer specific mortality) are better when salvage radiation is delivered at lower PSA values, there is no absolute cut-point to trigger treatment. Many factors must be taken in...
Would you treat a T2N0 high grade neuroendocrine carcinoma of the nasal cavity after a R1 resection?
Factors such as PNI or LVI are important to consider. In my practice, I always treat these patients. Nasal cavity resections are usually endoscopic resections that result in positive or close margin so adjuvant therapy is usually needed. High grade neuroendocrine cancers have high risk of local rec...
How long after surgery for a keloid can you wait to treat with post-operative radiation before the treatment becomes ineffective?
The literature has indeed shown "the sooner, the better."Initial studies looking at this question reported that the most effective time to give adjuvant radiation was within the first 1-2 weeks after excision. However, this treatment window was soon shortened to treatment delivery to be within 72 ho...