Radiation Oncology
Expert insights on radiation treatment planning, techniques, toxicity management, and multimodal cancer care.
Recent Discussions
What dose do you feel comfortable treating the entire circumference of an extremity to before you are concerned about chronic toxicity?
The doses for lymphoma will depend on the histology , use of chemotherapy , response to chemotherpy . I am comfortable in giving 3600cGy at 180 cGy per fraction .
How do you manage cranial radiotherapy in the setting of an acute CVA?
Location of the infarct is important to consider, like brainstem or cerebellum or MCA areas apart from functional status. Lesion (infarct) volume (measured on DW-MRI) is an objective surrogate marker for infarct resolution [Gaudinski et al., PMID 18635854]. Either a SPECT or PET/CT scans can be used...
How do you determine whether to offer whole lung radiation to children with favorable histology Wilms, lung metastases, and a CR on chemo, without knowledge of 1p16q status, as per the AREN0533 protocol?
With very small lung metastases to begin with , I would withhold whole lung radiation if a CR is achieved with chemotherapy.
Does the RTA proposed legislation that would remove technical payments for freestanding radiation oncology centers from the Medicare physician fee schedule help or hurt radiation oncologists in a freestanding center?
While ASTRO supports payment reform, I personally cannot support this particular bill as introduced by RTA. My main concern is the unknown impact on the professional services fees for radiation oncologists practicing in BOTH freestanding and hospitals. So, to answer the question as it was specifical...
What dose and volume would be recommended for a medically inoperable patient with a T4 rectal adenocarcinoma?
As is so often true, there is no absolute answer to a general question of this sort. It is much less common nowadays for a patient to be medically inoperable with the major advances in anesthesia. That being said, these patients certainly do appear. There is not a good literature on the proper dose....
Do you treat inguinal lymph nodes for patients with low lying vaginal cancers?
Yes we do. For distal vaginal cancers (not involving vulva) that have no enlarged nodes, we treat the medial inguinal nodes (e.g. nodes medial to the common femoral and saphenous veins) to 45 Gy. We do not treat the nodes lateral to the femoral vein (i.e., along the circumflex v) unless there are su...
Should one perform a sentinel node biopsy in a clinically negative axilla prior to neoadjuvant chemotherapy?
For an upfront clinically and radiologically negative axilla, where the SNLN is negative for disease after chemo, we don't change our RT field. For an upfront clinically and radiologically negative or positive axilla where SNLN is positive even after chemo, then normally they undergo full dissection...
If a SNB is positive after neoadjuvant chemo and mastectomy, should an axillary dissection be performed or xrt given to all?
Just to clarify, the Alliance 011202 study takes patients with involved axillary nodes before induction chemotherapy who fail to convert to node-negativity post-induction, and randomizes them to axillary dissection vs not. Everyone on the trial gets comprehensive regional RT. There are options for i...
Is it safe and appropriate to palliatively treat abdominal or thoracic tumors with concurrent chemotherapy when using fractions of 250-300 cGy?
I have routinely given 250cGy per fraction to total doses of 3500-3750cGy with single-agent radiosensitizing chemotherapy (usually 5-FU or capecitabine) without apparent significant toxicity, though we have not reviewed our data. So I generally consider this to be a safe regimen and consider it for ...
What RT margins do you use when treating Grade III anaplastic gliomas?
At the Cleveland Clinic, we extrapolate from the GBM literature and from the Cairncross RTOG 9402 and Van den Bent EORTC trials showing the benefit of chemotherapy, and thus deliver radiation with concurrent temozolomide. We typically treat to 5940 cGy in 33 fractions. We treat PTV1 to 5040 cGy and ...