Do you discontinue statin therapy when patients reach LDL levels way below their target goal with PCSK9 inhibitor therapy?

I will not routinely adjust statin dosing in patients on PCSK9 inhibitors unless their LDL levels fall below 15-25 mg/dl. In which case, I will reduce statin dosing to allow the LDL to rise above 15-25 mg/dl.

I would never stop the statin when the addition of the PCSK9i lowered LDL "way below their target". First, if their target is 55 mg/d and their LDL is in the 20-40 range on the two drugs, I might be very happy with that result, depending on the patient's level of risk. If the patient is concerned an...