Do you immediately discontinue sulfonylureas when initiating GLP-1 receptor agonists in patients with longstanding type 2 diabetes?

In a patient with an A1c <8% or with current issues with hypoglycemia while taking a sulfonylurea (SU), I would discontinue the sulfonylurea at the time I prescribe any highly effective medication for type 2 diabetes, including a GLP-1-based therapy. That would be with instructions to the patient to...

It is an interesting question. Sulfonylureas are old-established drugs for the treatment of diabetes, although they are becoming less popular due to their risk of hypoglycemia and the fact that there are now better drugs available for the management of hyperglycemia of diabetes. GLP-1 receptor agoni...

This is a question that requires qualification, as I rarely approach management so dogmatically. It is well known that the addition of GLP-1 RA therapy to patients with T2DM already on sulfonylurea treatment is additive in terms of glycemic control and so can result in hypoglycemia. The prescribing ...