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For a patient with metastatic colon cancer, KRAS WT, when would you consider using EGFR (cetuximab, panitumumab) over VEGF (bevacizumab) antagonists as inital therapy?

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Mednet Member
Mednet Member
Medical Oncology · Vanderbilt University Medical Center

Aside from obvious, when patients are contraindicated to bevacizumab due to recent surgery or bleeding, clotting, wound healing problems, I would consider first line if left sided colorectal cancer with negative KRAS, NRAS, BRAF. If you look at the survival benefit with Anti EGFR agents in first lin...

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