In patients with Stage 0 CLL who are clinically doing well and don't warrant treatment, do you typically obtain the CLL FISH Panel and p53 status?

I do a baseline CLL FISH Panel and p53 status on new patients with stage 0 CLL, less for determining treatment options at the moment, and more for an idea of their natural history. For patients with del17p or 11q, I may monitor more closely than patients with a more predicted indolent course.

Yes. A prognostic score (CLL-IPI) can predict the likelihood that these patients will need treatment over the next 5 years. CLL-IPI includes 5 variables, of which TP53/17P carries the highest weight.

Molica et al., PMID 27465919

SWOG 1925 is a randomized clinical trial evaluating early vs delayed trea...