How do you approach evaluation of a patient referred for mononeuritis multiplex and +SSB?

Step 1: A clinical syndrome of mononeuropathy multiplex always requires an EMG study. Is the primary mechanism of the MnM axonal or demyelinating?

If it is demyelinating, there are only two possible diagnoses: multifocal CIDP (Lewis Sumner syndrome, which can occur in the context of Sjogren's syndro...

I would look at the history/timeline of the illness and any other lab studies suggesting inflammation and/or immune activation, along with any family history of autoimmunity (or cancer).

Mononeuritis multiplex is primarily a result of small vessel vasculitis resulting in ischemia to nerves and often ...