How do you decide between the different oral longer acting levodopa medications?

The question would be, why are you changing, and what are you changing from? (i.e., are one of these your initial agent, a change due to Sinemet side effects, or a change because of motor fluctuations?) The current theory on dopamine replacement is "smoother is better," so the longer (and lower) you...

In general, I reserve Sinemet CR for bedtime dosing or for patients with tolerance issues with Sinemet IR. Otherwise, it is an inconsistent pill with a slow onset.

Stalevo, Rytary, and Crexont play similar roles in reducing off-time for patients on IR formulations. Availability/insurance coverage ma...