How do you manage limited intracranial disease from a metastatic large cell neuroendocrine tumor?

In our practice we are moving to focal management of limited intracranial disease for all pathologies, pushing WBRT out to last resort status.

LCNEC is a heterogeneous disease (Hiroshima K, Mino-Kenudson M. Transl Lung Cancer Res. 2017) with variable response to chemo therapy. Even more unclear is it...