How would you approach the treatment of borderline resectable pancreatic adenocarcinoma in an elderly patient (>80 years old) with a poor performance status who is not a surgical candidate?

First, I would recommend making sure that the patient had a surgical evaluation that included a multidisciplinary team with experience in pancreatic surgeries, if possible, including a discussion of whether other medical conditions can be treated to enable a potential surgery.

If after this assessmen...