How would you manage a patient with newly diagnosed synchronous triple positive and metaplastic triple negative breast cancers?

Aside from considerations about genetic testing given the dual primaries, and local therapy considerations which I would defer to surgery and rad onc, this case would raise the question of which (neo)adjuvant regimens to consider. I would assess the risk for both cancer independently, and then attem...

Even though metaplastic triple negative breast cancers are felt to be relatively chemo-resistant, responses are seen in the neoadjuvant setting and we typically recommend standard chemotherapy in these cases as we cannot clearly exclude a benefit as would be seen in other triple negative cases. If s...