How would you treat metastatic colon cancer in patients on dialysis?

Fortunately, our standard regimen of 5FU and oxaliplatin are quite safe to administer for patients with chronic renal insufficiency/on dialysis:

- 5FU is cleared through non-renal mechanisms and does not require any dose adjustments

- BUT...exposure to capecitabine is higher in patients with renal i...

I generally agree with Dr Pishvaian. I would like to emphasize that capecitabine is completely contraindicated. Dose should be reduced for GFR < 30 ml/min but this is not safe for dialysis patients and cannot be given on a continuous basis.

Neither FU or platinums need any dose adjustment and I usua...