How would you treat metastatic squamous esophageal carcinoma that is HER2 negative?

In general we would not check HER2 status in squamous cell tumors of the esophagus. I think FOLFOX would be a reasonable first line regimen. Others would be cisplatin with 5FU. There is no standard of care first line regimen. Another reasonable option would be carboplatin with paclitaxel.