If a patient on ovarian suppression with goserelin for ER+HER2- BC achieves post-menopausal-range estradiol levels but does not achieve post-menopausal FSH levels, is she suppressed?

Per the package insert and thinking about the mechanism of action with goserelin, FSH levels should be suppressed to follicular phase levels. This usually occurs within four weeks after initial administration of drug and remains in this range. This needs to be kept in mind when following FSH levels ...

Yes, goserelin most likely suppressed the ovarian function based on hot flashes. It is a super rare that goserlin does not work after 4 weeks. FSH is expected to go down with goserelin. After two to four weeks, after the surge, pituitary gland shuts down. Technically, measuring the FSH or estradiol ...