Is the presence of ubiquitin-specific peptidase 8 (USP8) genotype helpful in determining the risk of Cushing disease recurrence?

Indeed, a recent retrospective, multicenter, international study (Zhang et al., PMID 41785910) reported that patients with USP8-variant tumors are more likely to experience recurrence of Cushing's disease in comparison with patients with microadenomas that are USP8-wildtype (37% vs. 15% at 10 years)...

Some studies do suggest that corticotroph microadenomas carrying somatic USP8 mutations (about 45% corticotroph adenomas) are more likely to recur (Zhang et al., PMID 41785910).

However, at present, I do not think that this justifies routine genetic testing, as surveillance is always needed after bio...