Is there greater efficacy of TPO-RA in patients who have undergone a splenectomy?

The clinical trials and real world studies do not suggest that there is a difference in efficacy in general based on splenectomy status. In my experience, I have found that a few highly refractory patients have some improvement in responses to treatment with splenectomy. I do not generally think of ...

In the pivotal clinical trials of romiplostim and eltrombopag, there was no strong relationship between splenectomy status and treatment response. In my experience, however, some splenectomized patients exhibit dramatic, rapid increases in the platelet count when treated with a TPO-RA drug, presumab...