Is there any outpatient protocol for cisplatin/doxorubicin neoadjuvant chemotherapy for osteosarcoma?

Outpatient administration of cisplatin/doxorubicin (albeit at a slightly reduced cisplatin dosage of 100 mg/m²) protocol is documented in the BC Cancer out in Vancouver, British Columbia. We offer this at Roswell, with the addition of mannitol, but it is a long 8-hour day, and close follow-up is rec...

The standard doses are 75 mg/m² of dox and 120 mg/m² of CDDP - hard to deliver as an outpatient. Cisplatin is not a schedule-dependent drug, so if there were compelling reasons not allowing hospitalization, one could split the cisplatin into 2 or 3 weekly doses. The old NSCLC regimens used to give w...

We also administer cisplatin and doxorubicin as outpatient therapy to our adolescent and young adult (AYA) patients with osteosarcoma. We give the 60 mg/m² dose daily x2 but without the use of mannitol, following a literature search and consensus building to harmonize pediatric and medical oncology ...