What is the appropriate pediatric dose of litfulo for a preadolescent with refractory alopecia areata?

Given that Litfulo is not yet approved for preadolescents and data from clinical trials in this age group are not yet available, it's hard to know the optimal dosing. With that said, typically I would treat a preadolescent with refractory alopecia areata off-label with Litfulo 50 mg (i.e., the same ...

Litfulo only comes in 50 mg capsules. If you choose to use it in a younger patient, it may depend on the patient. There is more pediatric data for baricitinib, which is approved in Europe for atopic dermatitis down to age 6, and tofacitinib, which is approved in the US for younger children.