What is the role for checking uric acid levels in evaluation of SIADH in hospitalized older adults?

Uric acid is typically not a first-line test for evaluation of hyponatremia. It's usually used when trying to differentiate between hypovolemic states (not SIADH by definition) and euvolemic states (including SIADH). The utility stems from how uric acid is handled in the nephron, i.e., it's reabsorb...

I find it very helpful in the diagnosis of SIADH. As long as patients are not taking uric acid-lowering drugs, a serum uric acid level <3 is highly suggestive of SIADH in the appropriate clinical setting. In my experience, I see a lot of patients being treated for SIADH who do not have that diagnosi...