What is your approach to REM behavior disorder not adequately treated with melatonin and clonazepam?

Rule out comorbidities like sleep apnea or medications causing RBD. Optimize doses for melatonin and clonazepam, and consider dual therapy with these. Other options are gabapentin or pramipexole.

Thanks,
Sam Morkous

Make sure the melatonin is ER as RBD occurs in the early morning hours.

If both are at their max doses, then, in addition to making sure the bedroom environment is safe, I recommend rivastigmine.

HA