What is your approach to treating metastatic prostate cancer with primary resistance to GnRH analogues or early CRPC?

There is no one correct answer for every patient.

In general, patients who are primarily resistant to GnRH or who develop early CRPC and who have not received docetaxel in the hormone-sensitive setting, would be good candidates to receive docetaxel. For those who are elderly or frail, I would consi...