What is your first line treatment for progressive well differentiated metastatic (and unresectable) pancreatic neuroendocrine tumors?

I assume you mean by (Progressive) metastatic pNETs, patients who are already progressed on SSAs. There are many points to consider in these patients:

• Grade: Are we talking about G1/2 vs G3 NET? This will affect our decision and how aggressive we should be.
• Are the met lesions exclusively hepatic v...