What non-taxane chemotherapy can you partner with trastuzumab/pertuzumab for HER2+ breast CA if neuropathy either at baseline or with treatment becomes prohibitive?

For less neuropathic agents there are safety/efficacy data from the PHEREXA trial combining capecitabine with pertuzumab and trastuzumab (Urruticoechea et al JCO 2018). We also presented data on using gemcitabine with pertuzumab and trastuzumab in a small phase 1/2. (Soliman et al JCO 2016). The dat...

I just read this in practice update and though relevant so sharing to help answer your question

• In the randomized, phase III, MARIANNE trial, the authors evaluated the efficacy of trastuzumab emtansine (T-DM1), T-DM1 plus pertuzumab, and trastuzumab plus a taxane in 1095 patients with HER2-positive...