Would you feel comfortable combining MMF and an IL-17 blocker in a patient with both limited scleroderma and psoriatic arthritis?

We combine medications all the time! So the question is what is the risk-benefit? How bad psoriatic arthritis?

1. Otezla and orencia for scleroderma?
2. Otezla and MMF?
3. Why not IL-23? Vs IL-17?
4. Why not just methotrexate?

So many choices you have! Also, you can always start with both for 2-6months then w...

Not so comfortable due to increased possibilities of immunodeficiency complications, neoplasias long term.