Mednet Logo
HomeMedical OncologyQuestion

Would you give adjuvant pembrolizumab in a MSI-H oligometastatic colorectal cancer status-post resection that responded to neoadjuvant ICI?

1
2 Answers
Mednet Member
Mednet Member
Medical Oncology · Mayo Clinic

Only <5% of metastatic colorectal cancer is mismatch repair deficient (dMMR) or microsatellite instability-High (MSI-H). However, it is such an important predictive biomarker for quick, sometimes dramatic, and durable response to immunotherapy as seen in the first line studies (CheckMate 142, KEYNOT...

Register or Sign In to see full answer

Mednet Member
Mednet Member
Medical Oncology · Mary Lanning Healthcare Morrison Cancer Center/University of Nebraska Medical Center Adjunct Faculty

The question posed “Would you give adjuvant pembrolizumab in a MSI-H oligometastatic colorectal cancer status-post resection that responded to neoadjuvant ICI? is incomplete:

What kind of resection was it? Was it a resection of primary plus oligometastatic sites? Or was there a prior resection and a...

Register or Sign In to see full answer