Would you offer empiric lung SBRT for two growing FDG-avid lung lesions in a patient with severe COPD on oxygen?

This is a good question! The short answer is yes, most likely. Many patients are too high-risk to receive biopsies; this is decided by surgery/pulm/IR. Unless the patient has contraindications to RT or something like severe IPF (where treatment may be worse than the disease), I would likely offer th...

Yes. Recommend tissue-free MRD testing first as a baseline (methylation-based tumor fraction), and it reflexes automatically to liquid biopsy as well if positive. I don't think I can say which brand here, but it is well-known.