Would you offer further chemotherapy in the adjuvant setting after resection of an isolated liver met that developed shortly after completion of adjuvant FOLFOX for colon cancer?

This is a difficult question but is a scenario we meet from time to time in the clinic.

The first question is when we say shortly after completion of adjuvant FOLFOX, what is the interval between completion of FOLFOX and the liver metastatic lesion detection? Usually, we think it is a short period ...

I most likely will elect to observe this patient only.

Previously, the EORTC trial of peri-operative chemotherapy versus surgery alone, with up to four liver lesions, did not show a survival benefit with its updated publication in Lancet Oncology 2013.

Interesting data was presented in ASCO 2020 (#40...